LYMPHOID NEOPLASIA Mechanisms and clinical significance of BIM phosphorylation in chronic lymphocytic leukemia
نویسندگان
چکیده
1Cancer Research UK Centre, Cancer Sciences Unit, University of Southampton Faculty of Medicine, Southampton General Hospital, Southampton, United Kingdom; 2Molecular Immunology Group, Tenovus Laboratory, Cancer Sciences Division, Southampton University Hospitals Trust, Southampton, United Kingdom; 3Department of Haematology, University Hospital Trust, Southampton, United Kingdom; and 4Laboratory of Molecular Signaling, Babraham Institute, Cambridge, United Kingdom
منابع مشابه
Mechanisms and clinical significance of BIM phosphorylation in chronic lymphocytic leukemia.
B-cell receptor and microenvironment-derived signals promote accumulation of chronic lymphocytic leukemia (CLL) cells through increased proliferation and/or decreased apoptosis. In this study, we investigated the regulation of BIM, a proapoptotic BCL2-related protein, which is tightly regulated by phosphorylation. Surface IgM stimulation increased phosphorylation of 2 BIM isoforms, BIM(EL) and ...
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1Departament de Ciències Fisiològiques II, Institut d’Investigació Biomèdica de Bellvitge (IDIBELL)–Universitat de Barcelona, L’Hospitalet de Llobregat, Spain; 2Departament d’Hematologia Clínica, IDIBELL-Institut Català d’Oncologia, L’Hospitalet de Llobregat, Spain; 3Servei d’Hematologia, IDIBELL–Hospital de Bellvitge, L’Hospitalet de Llobregat, Spain; 4Division of Developmental Immunology, Bio...
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